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AIxBio Horizon Scan Winter 2025-2026

Paper

AIxBio Horizon Scan Winter 2025-2026

The AIxBio field stands at a critical juncture where rapid capability advances are outpacing governance frameworks and safety measures. The next 18 months will likely prove pivotal in determining whether voluntary safety practices by AI companies, emerging evaluation frameworks, and international coordination efforts can keep pace with technological development.

A Framework for Managed Access to Biological AI Tools

Paper

A Framework for Managed Access to Biological AI Tools

Managed access will be critical for reducing biosecurity risks related to the misuse of biological AI tools. By working to develop best practices for each element of this framework—risk levels, tiered access, and practices to verify legitimacy—developers of biological AI tools and the broader life sciences community can reduce risks while maintaining the benefits of these tools.

Guidance for Assessing Biosecurity and Biosafety Risks:

For the Purpose of Reviewing Research Proposals Prior to Funding

Paper

Guidance for Assessing Biosecurity and Biosafety Risks:

For the Purpose of Reviewing Research Proposals Prior to Funding

Funders play a key role in shaping how life science research is conducted. This new framework—developed collaboratively by a diverse group of internationally recognized experts—helps funders identify proposals that may require additional biosafety or biosecurity review and supports risk-mitigation efforts.

Safeguarding Against Global Catastrophe

Report

Safeguarding Against Global Catastrophe

AIxBio capabilities hold immense promise—but they also introduce unprecedented risks. The exploitation of AIxBio capabilities for harm is a plausible near-term risk—and the time for action is now. NTI | bio offers actionable recommendations for governments, industry leaders, and philanthropic organizations to prevent catastrophic misuse.

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