Fact Sheet

India Biological Overview

India Biological Overview

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Background

This page is part of the India Country Profile.

India has ratified the Biological and Toxin Weapons Convention (BTWC) and pledges to abide by its obligations. There is no clear evidence, circumstantial or otherwise, that directly points toward an offensive BW program. India has defensive biological warfare (BW) capabilities and has conducted research on countering various diseases. 1 India also has an extensive and advanced dual-use pharmaceutical industry.

Capabilities

New Delhi possesses the scientific capability and infrastructure to launch an offensive BW program, but does not appear to have chosen to do so. In terms of delivery, India also possesses the capability to produce aerosols and has numerous potential delivery systems ranging from crop dusters to sophisticated ballistic missiles. However, no information exists in the public domain suggesting interest by the Indian government in delivery of biological agents by these or any other means.

History

Since ratification of the BTWC on 15 July 1974, India has sought to improve its capabilities in biotechnology, largely in a peaceful capacity. India has a well-developed biotechnology infrastructure that utilizes well-trained scientists experienced with infectious diseases and numerous pharmaceutical production facilities and bio-containment laboratories (including labs at Biosafety Levels 3 and 4). In October 2002, Indian President A.P.J. Abdul Kalam asserted that India “will not make biological weapons. It is cruel to human beings…” 2

Some of India’s facilities are dedicated to developing defensive measures to combat biological attacks, and these same facilities potentially could be repurposed to provide offensive agents as well. India’s biodefense industry is centered at the Defense Research and Development Organization (DRDO), and its primary lab, the Defense Research and Development Establishment (DRDE), is located in Gwalior, Madhya Pradesh. 3

The DRDE is the primary establishment for studies in toxicology, biochemical pharmacology, and the development of antibodies against several bacterial and viral agents. Work here centers on countering disease threats such as anthrax, brucellosis, cholera, plague, smallpox, viral hemorrhage fever, and botulism. 4 Additionally, the Indian government has established nuclear, biological, and chemical (NBC) warfare directorates in the armed services, as well as an inter-services coordination committee to monitor the program. The Indian Army has further established an NBC cell at Army Headquarters to study the effects of NBC warfare. In 2003, the DRDO turned over India’s first indigenously produced NBC reconnaissance vehicle to the Indian army. 5

India has made substantial efforts to prepare its military force for a biological attack. In December 1998, India began to train its medical personnel to deal with the eventualities of such an attack. In 2001, India increased the scope of its countermeasures capability after the Indian Postal Department received 17 “suspicious” letters believed to contain Bacillus anthracis spores. Though a number of individuals and institutions received envelopes containing white powder, none ultimately tested positive for any spores, and the series of incidents is thought to have been a hoax. 6 However, a Biosafety Level 2 (BSL-2) laboratory was established at the Institute of Preventive Medicine to provide guidance in preparing the Indian government for a biological attack. 7 B. anthracis is one of many pathogens studied at the institute, which also examines pathogens causing tuberculosis, typhoid, hepatitis B, rabies, yellow fever, Lassa fever, Ebola, and plague. However, representatives of the Indian Army’s Medical Corps have publicly expressed reservations that Indian hospitals are adequately prepared for events arising from biological attacks. 8 India’s Central Industrial Security Force (CISF), originally established to defend heavy industry, transportation hubs, nuclear facilities and the like, has also developed the ability to deploy specially-trained first responders to the scene of a nuclear or biological attack. 9

In January 2003, the Indian government announced changes in India’s nuclear use doctrine and stated that the new posture allows India to “retain the option of retaliating with nuclear weapons” in the event of a major biological or chemical attack against India or Indian forces anywhere. 10 During this year, Indian security agencies also became concerned that terrorist groups could make use of ricin to launch biological attacks. These concerns grew after the discovery that al-Qaeda training manuals trained terrorists in the production and use of toxins such as ricin. In view of the terrorist attack on the Indian parliament in December 2002, an Indian parliamentary committee also considered plans for underground bunkers to protect members of parliament from a nuclear and biological attack. In the same month as the attack against the Indian parliament, Indian Defense Minister George Fernandes also indicated that “the government has initiated necessary steps to ensure protection from a nuclear and bio-attack.” 11 In an apparent follow-up, Home Minister Shivraj Patil indicated in August 2004 that Indian scientists were formulating a response to potential biological, chemical, and other non-conventional forms of terrorism.

BW-Related Export Controls

Although not a member of the Australia Group, India has stringent export control regulations outlined in the Special Chemicals, Organisms, Materials, Equipment, and Technologies (SCOMET) guidelines, India’s national export product control list that identifies goods, technologies and services subject to dual- use licensing requirements. 12 However, the SCOMET list does not encompass all dual-use items present on the Australia Group dual-use control list. Most notably the SCOMET list does not include P3 or P4 containment facilities (equivalent to BSL3 or BSL4 labs), fermenters, centrifugal separators, cross flow filtration equipment, freeze-drying equipment, aerosol inhalation chambers, and spraying/flogging systems. 13 In 2003, the U.S. sanctioned two Indian companies charged with violating Indian government regulations by supplying dual-use plant equipment to Iraq (during the Saddam Hussein era), for that country’s alleged chemical and biological weapons programs. 14

Recent Developments & Current Status

India’s biotechnology industry is rapidly expanding through its extensive and advanced dual-use pharmaceutical industry. Ensuring the security and standardization of the institutions and the facilities that handle biological materials remains a challenge. In January 2014, U.S. Food and Drug Administration representatives carried out a week-long inspection of a major pharmaceuticals complex, noting that quality control and the microbiology labs were in need of improvement. 15

On 3 June 2015, India and the United States signed a new 10-year defense framework agreement, which includes provisions to work cooperatively to develop defense capabilities, including “a lightweight protective suit effective in chemical and biological hazard environments.” 16

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Glossary

Biological and Toxin Weapons Convention (BTWC)
The BTWC: The Convention on the Prohibition of the Development, Production and Stockpiling of Bacteriological (Biological) and Toxin Weapons and on Their Destruction (BTWC) prohibits the development, production, or stockpiling of bacteriological and toxin weapons. Countries must destroy or divert to peaceful purposes all agents, toxins, weapons, equipment, and means of delivery within nine months after the entry into force of the convention. The BTWC was opened for signature on April 10, 1972, and entered into force on March 26, 1975. In 1994, the BTWC member states created the Ad Hoc Group to negotiate a legally binding BTWC Protocol that would help deter violations of the BTWC. The draft protocol outlines a monitoring regime that would require declarations of dual-use activities and facilities, routine visits to declared facilities, and short-notice challenge investigations. For additional information, see the BTWC.
Biological weapon (BW)
Biological weapons use microorganisms and natural toxins to produce disease in humans, animals, or plants.  Biological weapons can be derived from: bacteria (anthrax, plague, tularemia); viruses (smallpox, viral hemorrhagic fevers); rickettsia (Q fever and epidemic typhus); biological toxins (botulinum toxin, staphylococcus enterotoxin B); and fungi (San Joaquin Valley fever, mycotoxins). These agents can be deployed as biological weapons when paired with a delivery system, such as a missile or aerosol device.
Dual-use item
An item that has both civilian and military applications. For example, many of the precursor chemicals used in the manufacture of chemical weapons have legitimate civilian industrial uses, such as the production of pesticides or ink for ballpoint pens.
Ballistic missile
A delivery vehicle powered by a liquid or solid fueled rocket that primarily travels in a ballistic (free-fall) trajectory.  The flight of a ballistic missile includes three phases: 1) boost phase, where the rocket generates thrust to launch the missile into flight; 2) midcourse phase, where the missile coasts in an arc under the influence of gravity; and 3) terminal phase, in which the missile descends towards its target.  Ballistic missiles can be characterized by three key parameters - range, payload, and Circular Error Probable (CEP), or targeting precision.  Ballistic missiles are primarily intended for use against ground targets.
Anthrax
The common name of the bacterium Bacillus anthracis, as well as the name of the disease it produces.  A predominantly animal disease, anthrax can also infect humans and cause death within days.  B. anthracis bacteria can form hardy spores, making them relatively easy to disseminate.  Germany, the United Kingdom, the United States, and the USSR/Russia have all investigated anthrax as a biological weapon, as did the Japanese cult Aum Shinrikyo.  Anthrax-laced letters were also used to attack the U.S. Senate and numerous news agencies in September 2001.  There is no vaccine available to the general public, and treatment requires aggressive administration of antibiotics.
Cholera
Cholera: A disease of the digestive tract caused by the bacteria Vibrio cholerae. A water-borne disease, cholera infections usually occur via contaminated water or foods. Cholera causes severe diarrhea followed by severe dehydration, and can result in death within hours or days. Sanitation in the developed world has greatly lessened cholera’s public health impact. Unit 731 of the Japanese Imperial Army used cholera against the Chinese military and civilian populations during World War II.
Plague
Plague: The disease caused by the bacterium Yersinia pestis. There are three forms of plague: bubonic plague, pneumonic plague, and septicemic plague. Bubonic plague refers to infection of the lymph nodes by Y. pestis, causing black sores or “buboes,” pneumonic plague refers to infection of the lungs, and septicemic plague refers to infection of the bloodstream. Although no longer a serious public health hazard in the developed world, the bacterium can spread from person-to-person in aerosolized form, and has been investigated as a biological weapon by Japan and the Soviet Union.
Hemorrhagic fever viruses
A group of viruses that cause characteristic hemorrhaging (bleeding) resulting from damage to the vascular system and impairment of bodily regulation. The diseases caused by hemorrhagic fever viruses include Marburg, Ebola, Yellow fever, and Lassa fever.  Primarily found in rodents and arthropods, human outbreaks of viral hemorrhagic fevers are very rare and thus, they are less thoroughly understood than the more commonly occurring human viral diseases. The Soviet Union weaponized several hemorrhagic fever viruses including Marburg, Ebola, Lassa, and the New World arenaviruses Junin and Machupo. The United States weaponized Yellow fever and Rift Valley fever.  North Korea may have also weaponized hemorrhagic fever viruses.   
Botulinum Toxin
Botulism is caused by exposure to botulinum toxin (a neurotoxin).  Most often caused by eating contaminated foods, botulinum poisoning prevents the human nervous system from transmitting signals, resulting in paralysis, and eventually death by suffocation.  Botulinum toxin is the most toxic known substance. 15,000 times more toxic than VX nerve gas, mere nanograms of botulinum toxin will kill an adult human.  A significant bioweapons concern, botulinum toxin has been investigated as a weapon by Japan, the Soviet Union, the United States, Iraq and unsuccessfully by the Japanese cult Aum Shinrikyo. 
Pathogen
Pathogen: A microorganism capable of causing disease.
Typhoid fever
Typhoid fever: A disease spread through contaminated food, typhoid fever causes diarrhea and rash. While typhoid fever is now only a public health concern in developing countries, typhoid fever outbreaks during wartime have occurred numerous times. Caused by the bacterium Salmonella typhi, Japan investigated and allegedly used typhoid-based biological weapons during sabotage operations in World War II.
Yellow fever virus
The virus that causes Yellow fever, a viral hemorrhagic fever.  Yellow fever is naturally transmitted by mosquitoes, and remains common in many tropical and semi-tropical areas, particularly in Africa.  Yellow fever patients experience two disease phases.  The first brings flu-like symptoms while the second phase, or “toxic phase,” brings severe pain, vomiting, kidney failure, and bleeding from the mouth, eyes, and stomach.  While only 15 to 25 percent of patients will develop the toxic phase, half of those who do die.  Very little open literature about possible weaponization of Yellow fever virus exists.
Plague
Plague: The disease caused by the bacterium Yersinia pestis. There are three forms of plague: bubonic plague, pneumonic plague, and septicemic plague. Bubonic plague refers to infection of the lymph nodes by Y. pestis, causing black sores or “buboes,” pneumonic plague refers to infection of the lungs, and septicemic plague refers to infection of the bloodstream. Although no longer a serious public health hazard in the developed world, the bacterium can spread from person-to-person in aerosolized form, and has been investigated as a biological weapon by Japan and the Soviet Union.
Al-Qaeda or Al-Qa’ida
Al-Qaeda or Al-Qa'ida: A radical Islamist terrorist organization established by Osama bin Laden (now deceased), responsible for a number of attacks in the United States and worldwide, including the September 11, 2001 attacks on the World Trade Center and Pentagon. Al-Qa'ida means “the base” in Arabic, and acts as an umbrella organization for a number of terrorist groups around the world. The organization’s current leader is Ayman al-Zawahiri.
Toxin
Toxin: A poison formed as a specific secretion product in the metabolism of a vegetable or animal organism, as distinguished from inorganic poisons. Such poisons can also be manufactured by synthetic processes.
Australia Group (AG)
Australia Group (AG): Established in 1985 to limit the spread of chemical and biological weapons (CBW) through export controls on chemical precursors, equipment, agents, and organisms. For additional information, see the Australia Group.
Export control
National laws or international arrangements established to restrict the sale of certain goods to certain countries, or to ensure that safeguards or end-use guarantees are applied to the export and sale of sensitive and dual-use technologies and materials. See entry for Dual-use

Sources

  1. In 2012, the State Department reported that India did not engage in activities prohibited by the BWC, and therefore was not included in 2012, 2013, 2014, and 2015 reports. U.S. Department of State, "Adherence to and Compliance with Arms Control, Nonproliferation and Disarmament Agreements and Commitments," June 2015, www.state.gov; U.S. Department of State, "Adherence to and Compliance with Arms Control, Nonproliferation and Disarmament Agreements and Commitments," July 2014, www.state.gov; U.S. Department of State, "Adherence to and Compliance with Arms Control, Nonproliferation and Disarmament Agreements and Commitments," July 2013, www.state.gov; U.S. Department of State, "Adherence to and Compliance with Arms Control, Nonproliferation and Disarmament Agreements and Commitments," 2012, www.state.gov; U.S. Department of State, "Adherence to and Compliance with Arms Control, Nonproliferation and Disarmament Agreements and Commitments," August 2011, www.state.gov.
  2. "India Not to Make Biological Weapons: President," Press Trust of India, 28 October 2002, via www.lexis-nexis.com.
  3. Basrur, Rajesh M., Joseph, Mallika, "Chemical Biological, Radiological and Nuclear Terrorism Threats: A Case Study on India," Landau Network- Centro Volta South Asia Security Project: Case Study 1/2007, December 2007, pp 14, www.centrovolta.it.
  4. Basrur, Rajesh M., Joseph, Mallika, "Chemical Biological, Radiological and Nuclear Terrorism Threats: A Case Study on India," Landau Network- Centro Volta South Asia Security Project: Case Study 1/2007, December 2007, pp 14, www.centrovolta.it.
  5. “India's First NBC Recce Vehicle Launched in Pune,” DNA India, 22 December 2010, www.dnaindia.com.
  6. "Gov't Taking Steps to Set Up Special Courts," Times of India, 4 December 2001, www.timesofindia.indiantimes.com.
  7. "India: Tackling Bio-Terrorism: Specialized Lab Soon," The Hindu, 28 November 2001, www.thehindu.com.
  8. "In the Name of an NBC Attack," Economic Times, 10 November 2002, via www.lexis-nexis.com.
  9. “Special Force to Tackle Nuclear or Biological Attack in India,” Xinhua, 10 November 2002, news.xinhuanet.com.
  10. "India Establishes a Nuclear Command System," New York Times, 5 January 2003, www.nytimes.com.
  11. "Defense Ministry Hasn't Replied to CAG: George," Times of India, 19 December 2002, via www.lexis-nexis.com.
  12. "Guidelines for Exports of SCOMET Items," Directorate General of Foreign Trade, Ministry of Commerce and Industry, Government of India, http://dgft.gov.in; "India's Export Controls: Current Status and Possible Changes on the Horizon," SECURUS Strategic Trade Solutions, LLC., 10 July 2011, pp 3-4, www.securustrade.com.
  13. "Guidelines for Exports of SCOMET Items," Directorate General of Foreign Trade, Ministry of Commerce and Industry, Government of India, http://dgft.gov.in; "India's Export Controls: Current Status and Possible Changes on the Horizon," SECURUS Strategic Trade, LLC., 10 July 2011, pp 3-4, www.securustrade.com.
  14. "Suspected WMD-Related Dual-Use Goods and Procurement Transactions - Regime Finance and Procurement - Annex I," DCI Special Advisor Report on Iraq's WMD, 30 September 2004, www.cia.gov.
  15. "India NBC Capabilities-Biological", Jane's Nuclear, Biological, and Chemical Defence, 19 May 2014, www.janes.ihs.com.
  16. Jim Garamone, “U.S., India Sign 10-Year Defense Framework Agreement,” US Department of Defense, 4 June 2015, www.defense.gov.

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